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What cannabinoids there except CBD yet?

15/12/2020 7 MIN. READ Mirko Berger
15/12/2020 7 MIN. READ Mirko Berger

Introduction Cannabinoids 101

We're just at the very beginning of the expedition on cannabis and what made it so everything can be used as a medicinal plant. Have you ever wondered why cannabis is so versatile and there are so many applications for wellness and in the medical field? In this article you will learn more about the already familiar cannabinoids such as CBD and THC and other less prominent.

So far, found in the cannabis plant already more than 500 different fabrics code, including more than 144 cannabinoids. Other substances such as terpenes code and flavonoids, which are mainly responsible for the smell and taste of the flowers, place one also in other plants. That does not mean that they do not also have an effect on your body. of the two prominent representatives of the cannabinoids CBD and THC you've probably heard, perhaps from endocannabinoid system code, but we want to take a look at the other substances and how they affect your body. ' / p>

How do cannabinoids in the body?

have

All it long nobody knew about it and today we learn more: The endocannabinoid system. This system in your body was discovered in the early 1990s and consists of CB1 and CB2 receptors, which in turn interact with substances that makes your body itself, the endocannabinoids. Among the endocannabinoids include substances such as 2-AG, anandamide and 2-virohdamine arachidonoylglycerol. These substances act on the endocannabinoid system and ensure that the regulation of pain, your appetite and digestion, your immune system, muscle tension and blood pressure and many more remain in balance and function properly.

Device that balance out of joint, as this can lead to health problems ranging ranging from arthritis, depression, insomnia to Crohn's disease. Here, the cannabis plant comes into play. It also produces cannabinoids, including phyto-cannabinoids called, and these are similar to the body's own substances so much that they affect also to the CB1 and CB2 receptors can bind and so the endocannabinoid system. The supply of cannabinoids so can restore the balance and reduce as possible physical suffering

.

What cannabinoids are available in the cannabis plant?

We are still at the beginning of the expedition, what everything is in cannabis, which must be due to his false reputation as evil weed over the years. Today it is more than 144 different cannabinoids. These are prepared in the cannabis plant and converted by environmental influences such as heat, light and oxidation in other forms. Thus, a fabric take several steps and carry other names. THC begins as his life in the cannabis plant as CBGA, then becomes THCA and then finally to the THC from which you've probably heard again. Very similar names, for example, an additional letter revealed several plastic molds. Here, the difference in the chemical formula may seem small, but have a big impact. The degree of psychological activity of the substance, for example, is changing, and also possibly the therapeutic application.

For the Cannbinoide act not all the same and activate the endocannabinoid system in different ways. If the plant is absorbed into the body (by smoking, about food than oil, or otherwise) there is still a surprise guest or Community Guests at the party in the endocannabinoid system: the terpenes, flavonoids and other cannabinoids in hemp. Together, these substances act in synergistic effect on your body. This is called Entourage effect. As with any party, the mood and dynamics change with the composition of the guests. This composition is also what the discussion of one or another cannabis set in motion at all.

Note: If the cannabinoid an A at the end of this is the acid form, which is then converted by decarboxylation in the neutral form

.

THCA

THC / A or THC acid. This is the acid form of tetrahydrocannabinol, which still has no psychoactive effects. In the US, it can be purchased as a crystalline powder in the dispensaries. Most users then heat it to make THC / A THC and then to activate the psychoactive effects. There are also capsules on the market, should have the therapeutic benefits. Evidence still lacking, however.

THCV

A popular cannabinoid is THCV or tetrahydrocannabivarin. It is very similar to THC, but has a slightly different mode of action. It can be used for anxiety disorders code and can even reverse the effects of THC, which itself sometimes can trigger anxiety. There is also evidence that it helps in weight loss by reducing appetite and boosting metabolism. Some studies point to the positive effect on the insulin production may have . There are also indications that THCV can promote the growth of new bone cells and effects in Parkinson require further research.

CBDV

This cannabinoid, known as Cannabidivarin, is still relatively unexplored, but if you know CBD, this relative is perhaps worth a try. The effect is similar to CBD. It has been shown in studies that CBDV can significantly reduce the number of seizures in patients with epilepsy code. In a study with rats, the efficacy of CBDV proven anti-nausea could be code.

CBC

CBC or cannabichromene also has therapeutic effect. So it can be for example as antibiotics used against resistant germs code - but so far only in the Petri dish. There are analgesic code and anti-inflammatory properties found when combined with THC. For the brain, it can work against neurodegenerative diseases such as Alzheimer. It promotes the growth of brain cells that are responsible for learning and memory functions.

CBCV

CBCV even Cannabichromevarin, similar to the cannabinoid CBC and him are said to have similar effects. Unfortunately, there is to this cannabinoid far hardly or no studies.

CBG

CBG, cannabigerol, is a common cannabinoid both cannabis and in Nutzhanfpflanzen occurs. It is not psychoactive and is therefore well suited for people who want to achieve no psychoactive effects of cannabinoids. Nevertheless, this cannabinoid has therapeutic effects. Studies suggest that it may be an effective pain killer code and entzündungshemmend code. It also neuroprotective properties were found that can be used for example against the Huntington's disease. This hereditary disease affects the brain and causes involuntary, uncoordinated movements. A positive supportive therapeutic effect was also observed in cancer code, Prostatakrebs code and examined oral cancer code.

In diseases of the eye, it can be used to code lowering intraocular pressure and can thus help with glaucoma. Hope this cannabinoid code also in the combat resistant strains of bacteria such as MRSA. Even for people who skin diseases such as psoriasis or psoriasis suffer, it can remedy the situation and relief , Studies in rats have found an effect on neurotransmitter code and thus mood, maybe this will lead to the development of new types of antidepressants .

CBGV

CBGV or Cannabigerovarin is for its pain-relieving and anti-inflammatory properties known and this are scientifically proven for mice. For dry skin and hautendzündliche diseases promises this cannabinoid also relief, which makes this particularly Cannabionoid. Also in cancer it could achieve positive effects. Thus, there are indications that CBGV the growth of leukemia cells inhibits code.

CBN

CBN or cannabinol produced during decay process of THCA. Does not sound sexy, but many underestimate the effect of this cannabinoid. Many users assume that cannabinol is a depressant. But the fact is that it is non-sedative in pure form, but the mix is ​​critical, or the combination with THC code.

Investigations (primarily rats) show that CBN to stimulate appetite code, against glaucoma and act as an antibiotic can . it in the ALS research (amyotrophic lateral sclerosis) are also promising approaches in mice that the outbreak can be delayed by ALS by CBN. Further studies also and especially in humans are urgently needed to confirm the supposedly positive effect.

CBL

cannabicyclol (CBL) develops when Cannabichromene (CBC) are heated and occurs more commonly in cannabis, which already supports a time. The state of research about this cannabinoid very thin because the concentration is very low in the plant. Studies were conducted to prostaglandin production and with no result. Some scientists expect positive effects in inflammatory and tumor cells, but this is still so a lot of research is needed.

What are synthetic cannabinoids?

blessing and calamity

While cannabis in recreational use and now also for medical purposes is large and growing in popularity, also be produced synthetic cannabinoids in the laboratories that activate the same receptors in the body such as cannabis. Some of them have gone through strict drug approval process and are patient as a treatment option. But other synthetic cannabinoids have not allowed any testing behind them and are, but still ticked on the road as designer drug. This is not necessarily helpful to polish the sleazy image of cannabis and its cannabinoids and provide its serious therapeutic effect to the fore.

Let's look first at the blessing. Two of the approved drugs based on synthetic cannabinoids, are dronabinol and nabilone, both AIDS patients used for the treatment of nausea and vomiting associated with chemotherapy and loss of appetite and weight loss in. These are so developed under laboratory conditions and tested and are approved as prescription drugs.

Spice and K2, however, are found in this case the evil and on the road. No one knows exactly what is and in these designer drugs in it which cannabinoid here now acts. Sometimes there are even no cannabinoids, but also other active ingredients that are purely mixed, such as hallucinogens and synthetic opioids. The side effects can be dramatic here: respiratory disorders and kidney damage have been associated with these synthetics in connection

. use

Patients who use cannabis as a medicine, so the natural cannabinoids continue to pull the synthetic cannabinoids before, because Mother Nature has created a balance between the cannabinoids in the plant to which the laboratories probably not approach. To code to examine the ingredients accurately, individual components must be considered of course isolated, but perhaps are cannabinoids simply more than the sum of its parts. At least there is still much to learn about the many cannabinoids and their myriad possibilities of application.

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