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#Science

CBD and Corona: What is the current state of the science?

21/12/2020 6 MIN. READ Mirko Berger
21/12/2020 6 MIN. READ Mirko Berger

April 2020, a year after COVID-19 (also: SARS-CoV-2) was more described for the first time, the world is still firmly in control of the corona virus. In addition to hope-giving news to vaccines, also various rumors on the Internet haunt around, saying that CBD as a cure for the virus could be used.

Everything just humbug, or is there actually something to it? We look at the current state of science and bring order to the chaos around CBD and COVID-19th

How accesses COVID-19 the element?

In the first months of the pandemic, the big question that needed to be clarified, the SARS-CoV-2 virus penetrates exactly how the body and damages several organs was there. Meanwhile, researchers know that COVID-19 converting angiotensin via the enzyme 2, reaches as ACE2 known in human cells. ACE2 has said a protein on the surface of many cell and tissue types, including lung, heart, blood vessels, kidneys, liver and gastrointestinal tract and is greatly simplified for the regulation of cellular functions responsible.

One of the important functions of ACE2 is the regulation of strong Blutgefäßverengers angiotensin II (ANG II). href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347488/">, it prevents this his normal role in the control of ANG II met signaling. ANG II can increase inflammation and death of cells in the alveoli, which are crucial for the introduction of oxygen into the body. These harmful effects of ANG II are reduced by ACE2. If the ACE2 activity "inhibited" by the virus is more ANG II available and its effect is enhanced. This overactivity of the inflammatory processes in the body probably contributes to damage, especially the lungs and heart, in COVID-19 patients in.

CBD may reduce COVID-19 lung damage

Perhaps the most interesting aspect of CBD in terms of COVID-19 is its anti-inflammatory effect. Numerous studies support the theory that cannabis-derived CBD patients can help by COVID-19 suffering from severe pneumonia caused. study by researchers at the University Augusta, Georgia code suggests that CBD in acute respiratory distress syndrome (ARDS) - a dangerous symptom in COVID -19 caused by an overactive inflammatory response - can help. This is called "cytokine storm" code. The authors of the study explain that "currently out of support measures there is no definitive cure for ARDS, illustrates what the urgent need for more creative and effective therapeutic modalities for the treatment of this complex disease."

The study by the University Augusta in Georgia was conducted in mice and is therefore less meaningful. The researchers induced ARDS first artificially with symptoms similar to patients with severe COVID-19 course. This produced a cytokine storm, the blood oxygen saturation was reduced by ten percent and even caused structural damage to the lungs. After the mice the cytokine storm and the simultaneously occurring shortness of breath had experienced, they received CBD. The results showed how strong CBD products in the treatment of ARDS can be. "The symptoms were completely or partially reversed and returned after treatment with CBD to the level and condition of the normal state back," report the authors.

The data from the study "supports the notion that the anti-inflammatory function of CBD reduce the cytokine storm and can mitigate the effects of excessive inflammation." "It is plausible that the CBD as a therapeutic candidate variety in the treatment of inflammatory diseases, including COVID -19 and other virus-induced ARDS can be used, "added the authors of the study. Of course, have they in the further point out that "more studies are needed obviously to expand this therapeutic strategy and validate".

Can protect a cannabis mouthwash against infection?

But that's not all: A Canadian research duo believes that a special kind of cannabis could possibly be a valuable tool in the fight against COVID-19th Olga and Igor Kovalchuck develop and test for years new varieties of cannabis with the aim of developing a variety that helps to fight cancer and inflammation. Since COVID-19 came into our lives, the duo focused on developing a cannabis strain that people for a coronavirus infection might be less prone to make.

The preclinical study brings us back to ACE2. The theory of researchers states that a cannabis variety may be used with a particularly high CBD portion to control the formation of ACE2 in the target tissue. According to the theory, the CBD extract would be used to reduce the level of ACE2 gene expression and temporarily include substantially the virus, the doors to the cells. Unfortunately, the proposed mechanism is at present only a theory.

"While our most effective extracts further validation require large scale, our study for future analysis of the impact of medical cannabis on COVID-19 is crucial. The extracts of our most successful and most novel C. sativa lines with high CBD content can (...) a useful and safe supplement for the treatment of COVID-19 as adjunctive therapy be, "says the study. Should researchers be able to prove their hypothesis, the next step with this would be a cannabis strain to develop a medical product in the form of a Mündspülung. Until then, however, the theory remains no more than an interesting and unusual idea.

terpenes and CBD against Corona

Part of the research in this area has focused on the ability of cannabinoids and terpenes. The idea is to attenuate the overreaction of the immune system, but without suppressing it. first results of a study that presently and in the cannabis research and development company CannaSoul Analytics is performed from Israel terpene manufacturer Eybna seem to suggest that the combination of terpenes and cannabinoids up to twice as effective is about to reduce by COVID-19 resulting inflammation, as the corticosteroid dexamethasone.

The study deals with a terpene formulation called NT VRL ™, which was developed by Eybna for the treatment of inflammatory diseases that have been observed in some COVID-19 patients in the form of the resulting Zytokinsturmsyndrom. This formula contains 30 different terpenes, the potential anti-inflammatory substances and are generally considered safe for consumption. While alone average CBD inhibits about 75 percent of the cytokines, the terpenes reached an inhibition of 80 percent, suggesting that the terpene mixture of Eybna in the inhibition of inflammation may be more effective than the CBD.

The data scientist Nadav Eyal, co-founder and CEO of Eybna said in a Forbes article that the company "biological data mining, data processing and formulation design" has used to develop a formulation that effectively aimed at certain health conditions "as z. B. Zytokinstürme. He says that this development method "opens up a new world for synergistically effective natural formulations have therapeutic abilities, which will have a single pharmaceutical agents difficulty keeping up."

Another new approach, which is currently being studied in Israel, is to develop a potential cell therapy in the CBD loaded exosomes (small vesicles, which are released from cells) are used to treat COVID-19 patients. The aim of this technology, it is, "and targeting both indications of the central nervous system to the COVID-19-coronavirus". CBD-loaded exosomes have to achieve the potential to be a highly synergistic effect of anti-inflammatory properties by targeting specific damaged organs such as infected lung cells.

What NOT the studies say

So what does all this research for us? Firstly, the different research approaches prove once again that the cannabis plant an enormous and still has before Unexplored potential. Secondly, it gives hope that we could have not only an inoculant against COVID-19 in the near future, but perhaps one or more promising treatment approaches.

Very important to emphasize

, however, that all the studies discussed in this article have not been conducted on humans and CBD is nothing to prove or to treat COVID-19 admitted. Although a few studies give hope, there is currently no scientifically reliable knowledge about whether the CBD can actually help COVID-19th

It should therefore nobody get the idea, treat yourself to these few studies themselves with CBD. Physicians also strongly advise from them on their own CBD for the prevention or treatment of COVID-19 to be used. Those who were already infected in the worst case, immediate medical advice should take and start any self-tests!

To help us in the CBD Corona pandemic

Corona scares us. And puts us under stress. We are afraid to infect us, possibly seriously ill, losing our job or love people. Corona makes us lonely. Many people have not seen their families, friends and colleagues for weeks or months and often experience an unprecedented level of loneliness.

In order to preserve the nerves in these times, a healthy routine is essential - and just that CBD can help. So can the daily dose CBD become an anchor that gives us peace and serenity. In conjunction href="https://vaay.com/blogs/cbd-magazin/schlafen-mit-cbd"> with a healthy sleep patterns, good diet and meditation, supported CBD code to keep the stress at bay and stay physically and mentally healthy.

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